Arabinoxylan-Based Mucoadhesive Oral Films of Tizanidine HCL Designed and Optimized Using Central Composite Rotatable Design

作者：Zaman Muhammad; Hanif Muhammad^*; Khan Mahtab Ahmad

来源：Polymer - Plastics Technology and Engineering, 2018, 57(5): 471-483.

DOI：10.1080/03602559.2017.1324575

• Alkali extraction
• ex vivo mucoadhesion
• in vitro dissolution and ex vivo permeation
• ispaghula husk
• SEM
• XRD

In the current study, a natural pharmaceutical excipient, arabinoxylan, was extracted from ispaghula husk and used to develop controlled release of mucoadhesive oral films of tizanidine hydrochloride. Film formulations were designed and optimized by central composite rotatable design, selecting arabinoxylan (X1) and glycerol (X2) as variables. Prepared films were evaluated for chemical compatibility of the ingredients, surface morphology, mechanical strength, in vitro drug release, ex vivo drug permeation and ex vivo mucoadhesion strength. Results revealed that selected ingredients were compatible and quite capable of producing films with desired characteristics.
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• 出版日期2018