Accelerated T-2 Mapping for Characterization of Prostate Cancer

作者：Liu Wei^*; Turkbey Baris; Senegas Julien; Remmele Stefanie; Xu Sheng; Kruecker Jochen; Bernardo Marcelino; Wood Bradford J; Pinto Peter A; Choyke Peter L

来源：Magnetic Resonance in Medicine, 2011, 65(5): 1400-1406.

DOI：10.1002/mrm.22874

• prostate cancer
• k-space undersampling
• T-2 mapping

Prostate T-2 mapping was performed in 34 consecutive patients using an accelerated multiecho spin-echo sequence with 4-fold k-space undersampling leading to a net acceleration factor of 3.3 on a 3T scanner. The mean T-2 values from the accelerated and conventional, unaccelerated sequences demonstrated a very high correlation (r = 0.99). Different prostate segments demonstrated similarly good interscan reproducibility (p = not significant) with slightly larger difference at base: 2.0% +/- 1.6% for left base and 2.1% +/- 1.1% for right base. In patients with subsequent targeted biopsy, T-2 values of histologically proven malignant tumor areas were significantly lower than the suspicious looking but nonmalignant lesions (p < 0.05) and normal areas (p < 0.001): 100 +/- 10 ms for malignant tumors, 114 +/- 23 ms for suspicious lesions and 149 +/- 32 ms for normal tissues. The proposed method can provide an effective approach for accelerated T-2 quantification for prostate patients. Magn Reson Med 65:1400-1406, 2011.

• 出版日期2011-5
• 单位NIH