The Significance of Alteration 2-[fluorine-18] fluoro-2-deoxy-D-glucose Uptake in the Liver and Skeletal Muscles of Patients with Hyperthyroidism

作者：Chen Yen Kung^*; Chen Yen Ling; Tsui Chih Cheng; Wang Su Chen; Cheng Ru Hwa

来源：Academic Radiology, 2013, 20(10): 1218-1223.

DOI：10.1016/j.acra.2013.06.005

• 2[fluorine-18]fluoro-2-deoxy-D-glucose
• liver
• positron emission tomography
• skeletal muscle
• thyroid hormone

Rationale and Objectives: Hyperthyroidism leads to an enhanced demand :for glucose. The hypothesis of the study is that 2-[fluorine-18] fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) can demonstrate the alteration of systemic glucose metabolism in hyperthyroidism patients by measuring the FDG standard uptake value (SUV) in liver and skeletal muscle. %26lt;br%26gt;Materials and Methods: Forty-eight active hyperthyroidism patients and 30 control participants were recruited for the study. The intensity of FOG uptake in the liver and thigh muscles was graded subjectively, comprising three groups: group I, higher FDG uptake in the liver; group II, equal FOG uptake in the liver and muscles; and group III, higher FOG uptake in the muscles. Ten subjects with FOG PET scans at hyperthyroid and euthyroid status were analyzed. Serum levels of thyroxine (T-4) and triiodothyronine (T-3) correlated to the SUVs of the liver and muscles. %26lt;br%26gt;Results: Forty-one patients (41/48, 85.4%) showed symmetrically increased FOG uptake in the muscles (22 in group I, 9 in group II, and 17 in group III). Group I patients were significantly older than group II (P = .02) and group III (P = .001) patients. The correlation coefficient between the serum T-3, T-4, and SUV levels in the muscles was significant (r = 0.47-0.77, P %26lt; .01), particularly in liver and muscle FOG uptake between hyperthyroid and euthyroid states. In the 30 control subjects, there was normal physiological FOG uptake in the liver and muscles. %26lt;br%26gt;Conclusion: In PET scans showing a pattern of decreased liver and increased skeletal muscle FOG uptake in hyperthyroidism patients, this change of FOG distribution is correspondence to the severity of hyperthyroidism status.

• 出版日期2013-10