Limitations of Significance Testing in Clinical Research: A Review of Multiple Comparison Corrections and Effect Size Calculations with Correlated Measures

作者：Vasilopoulos Terrie; Morey Timothy E; Dhatariya Ketan; Rice Mark J^*

来源：Anesthesia and Analgesia, 2016, 122(3): 825-830.

DOI：10.1213/ANE.0000000000001107

Modern clinical research commonly uses complex designs with multiple related outcomes, including repeated-measures designs. While multiple comparison corrections and effect size calculations are needed to more accurately assess an intervention's significance and impact, understanding the limitations of these methods in the case of dependency and correlation is important. In this review, we outline methods for multiple comparison corrections and effect size calculations and considerations in cases of correlation and summarize relevant simulation studies to illustrate these concepts.

• 出版日期2016-3