Asymmetric nitroaldol reaction using nitromethane labeled with (11)C

作者：Kato Koichi^*; Gustavsson Sven Ake; Langstrom Bengt

来源：Tetrahedron Letters, 2008, 49(41): 5837-5839.

DOI：10.1016/j.tetlet.2008.07.074

Nitro [(11)C]methane produced from [(11)C]O(2) reacted with several aldehydes in the presence of chiral metal catalyst prepared from LaLi(3)(tris(binaphtoxide)), n-BuLi, H(2)O, and (R)-binaphtol. The Molar ratios of La, Li, and binaphtol for effective catalysis in the (11)C-labeling were 1/4/4.5 and 1/4/6, respectively. The (11)C-nitroaldol products were obtained in 3-25% radiochemical yields with 39-51 % ee within 20 min starting from the preparation of nitro[(11)C]methane.

• 出版日期2008-10-6