Andirolides W-Y from the flower oil of andiroba (Carapa guianensis, Meliaceae)

作者：Sakamoto Asami; Tanaka Yuji; Yamada Takeshi; Kikuchi Takashi; Muraoka Osamu; Ninomiya Kiyofumi; Morikawa Toshio^*; Tanaka Reiko

来源：Fitoterapia, 2015, 100: 81-87.

DOI：10.1016/j.fitote.2014.09.003

• Andirolides W-Y
• Carapa guianensis
• Flower
• Meliaceae
• Limonoid
• NO production

Three new limonoids, andirolides W-Y (1-3), were isolated from the flower oil of Carapa guianasis AUBLET (Meliaceae). Their structures were elucidated on the basis of spectroscopic analyses using 1D and 2D NMR spectra and FABMS. Seven known limonoids: 7-deacetoxy-7-oxogedunin (4), 6 alpha-acetoxygedunin (5), methylangolensate (6), 6 alpha-hydroxygedunin (7), 6 alpha-acetoxy-7 alpha-deacetoxy7 alpha-hydroxygedunin (8), gedunin (9), and 7-deacetoxy-7-hydroxygedunin (10) from this flower oil were evaluated for the effects on the production of NO in LPS-activated mouse peritoneal macrophages.

• 出版日期2015-1