Evaluation of the National Toxicology Program Report on Carcinogens

作者：Rodu Brad^*; Cole Philip; Mandel Jack S

来源：Regulatory Toxicology and Pharmacology, 2012, 64(1): 186-188.

DOI：10.1016/j.yrtph.2012.07.002

• National Toxicology Program
• Report on Carcinogens
• Known human carcinogens
• Reasonably anticipated carcinogens
• Probable human carcinogens
• Possible human carcinogens
• International Agency for Research on Cancer
• Monographs

This study evaluates the National Toxicology Program%26apos;s Report on Carcinogens program (RoCP) and compares it with the International Agency for Research on Cancer Monographs Program (IMP). We tracked agents classified in the RoCP since 1983 as known human carcinogens (A-List), or as reasonably anticipated to be human carcinogens (B-List). The first A-list included 24 agents, and twenty-four unique agents were added in the following 28 years; twenty were listed by IMP as Group 1 (carcinogenic to humans) 7 years before their A-list appearance. Group 1 also includes 30 or more agents eligible for, but not on, the A-list. The first B-list included 98 agents, and this increased to 185. Of these, 39 are in Group 2A (probably carcinogenic), and 122 are in Group 2B (possibly carcinogenic). Only 5% of the 204 agents ever on the B-list have been upgraded to the A-list. The RoCP is severely limited because it evaluates few agents and because its B-list does not distinguish between probable and possible human carcinogens. Further, it mislabels likely non-carcinogens as reasonably anticipated to be carcinogens. If the RoCP were terminated there would be no loss or delay of information available to scientific, public health and regulatory communities.

• 出版日期2012-10