A sub-minute electrophoretic method for simultaneous determination of naphazoline and zinc

作者：Ribeiro Michelle M A C; Oliveira Thiago C; Batista Alex D; Munoz Rodrigo A A; Richter Eduardo M

来源：Journal of Chromatography A, 2016, 1472: 134-137.

DOI：10.1016/j.chroma.2016.10.031

• Fast separation
• Capillary electrophoresis
• Short column
• Contactless conductivity detection
• Organic and inorganic compounds

This paper reports for the first time, a method for simultaneous determination of naphazoline (NPZ) and zinc (Zn) using an analytical separation technique (capillary electrophoresis with capacitively coupled contactless conductivity detection-CE-(CD)-D-4). A single run is possible every 55 s (sampling rate=65 h(-1)). The separation by CE-(CD)-D-4 was achieved on a fused silica capillary (50 cm length - 10 cm effective, 50 mu m i.d.) with a background electrolyte (BGE) composed by 20 mmol L-1 of 2-(morpholin-4-yl)ethane-1-sulfonic acid (MES) and 20 mmol L-1 of histidine (HIS) (pH 6.0). Detection limits were estimated at 20 and 30 mu mol L-1 and recovery values for spiked samples were 98 and 102% for NPZ and Zn, respectively. The developed procedure was compared to HPLC (NPZ) and FAAS (Zn) and no statistically significant differences were observed (95% confidence level).

• 出版日期2016-11-11