Novozym 435-catalyzed synthesis of polyetheramides from amino-esters, or diesters and diamines built on ethylene- and diethylene- glycol moieties

作者：Poulhes Florent; Mouysset Dominique; Gil Gerard; Bertrand Michele P; Gastaldi Stephane^*

来源：Polymer, 2012, 53(6): 1172-1179.

DOI：10.1016/j.polymer.2012.01.054

• Polyetheramides
• Enzymatic polymerization
• CAL-B

The optimization of CAL-B-promoted (Novozym 435) A/B and AA/BB type polymerizations leading to polyetheramides, from amino ethylesters or diethyl esters and diamines based on ethylene- or diethylene-glycol moieties, is disclosed herein. From these preliminary experiments it became obvious that it is of prime importance: to avoid the presence of water by carefully drying the enzyme prior to use; to eliminate ethanol from the reaction medium, by working under reduced pressure in order to drive the amidation reaction forward; to select an appropriate high boiling solvent, the best choice being diphenyl ether. Under such experimental conditions, polyetheramides were obtained in 70-80% yield with an average degree of polymerization (DPn) up to 17.

• 出版日期2012-3-9