Asymmetric synthesis of ethano-Troger bases using CuTC-catalyzed diazo decomposition reactions

作者：Sharma Ankit; Besnard Celine; Guenee Laure; Lacour Jerome^*

来源：Organic and Biomolecular Chemistry, 2012, 10(5): 966-969.

DOI：10.1039/c1ob06751f

Nonracemic ethano-bridged Troger bases are prepared using CuTC-catalyzed decompositions of diazo compounds. Excellent levels of diastereo-and enantio-control (dr and ee up to 12 : 1 and 95% respectively) are now obtained with aryl diazoketone precursors.

• 出版日期2012