Automatic Detection of CT Perfusion Datasets Unsuitable for Analysis due to Head Movement of Acute Ischemic Stroke Patients

作者：Fahmi Fahmi^*; Marquering Henk A; Streekstra Geert J; Beenen Ludo F M; Janssen Natasja N Y; Majoie Charles B L; vanBavel Ed

来源：Journal of Healthcare Engineering, 2014, 5(1): 67-78.

DOI：10.1260/2040-2295.5.1.67

• brain CT perfusion
• computer aided detection
• acute ischemic stroke
• patient movement

Head movement during brain Computed Tomography Perfusion (CTP) can deteriorate perfusion analysis quality in acute ischemic stroke patients. We developed a method for automatic detection of CTP datasets with excessive head movement, based on 3D image-registration of CTP, with non-contrast CT providing transformation parameters. For parameter values exceeding predefined thresholds, the dataset was classified as `severely moved'. Threshold values were determined by digital CTP phantom experiments. The automated selection was compared to manual screening by 2 experienced radiologists for 114 brain CTP datasets. Based on receiver operator characteristics, optimal thresholds were found of respectively 1.0 degrees, 2.8 degrees and 6.9 degrees for pitch, roll and yaw, and 2.8 mm for z-axis translation. The proposed method had a sensitivity of 91.4% and a specificity of 82.3%. This method allows accurate automated detection of brain CTP datasets that are unsuitable for perfusion analysis.

• 出版日期2014-3