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摘要
Jacobson's necessary condition for optimality guarantees non-negativity of singular second variation, independently of generalized Legendre-Clebsch condition. Fed-batch is a typical singular bioprocess system. However, no reports exist of using Jacobson's necessary condition in fed-batch optimization problem. This paper suggests its applicability to fed-batch optimization problem by showing its analytical studies for two typical examples: cell mass and metabolite maximization problem.
- 出版日期2011-3
