Microwave promoted one-pot synthesis of 2-aryl substituted 1,3,4-oxadiazoles and 1,2,4-oxadiazole derivatives using Al3+-K10 clay as a heterogeneous catalyst

作者：Suresh Dhanusu; Kanagaraj Kuppusamy; Pitchumani Kasi^*

来源：Tetrahedron Letters, 2014, 55(27): 3678-3682.

DOI：10.1016/j.tetlet.2014.05.004

• K10-montmorillonite
• 1,3,4-Oxadiazoles
• 1,2,4-Oxadiazoles
• One-pot solvent-free synthesis
• Green protocol

An efficient, inexpensive method is developed for the one-pot synthesis of 2-aryl substituted 1,3,4-oxadiazoles and 1,2,4-oxadiazoles starting from acid hydrazides and trimethyl orthoformate under solvent-free, microwave conditions using a reusable Al3+-K10 montmorillonite clay as a heterogeneous catalyst. The novelty of the present study lies in the synthesis of oxadiazole and benzimidazole moieties in a onepot process in high yield from easily available precursors and catalysts under mild conditions.

• 出版日期2014-7-2