Advances in Structural Modifications and Biological Activities of Berberine: An Active Compound in Traditional Chinese Medicine

作者：Huang, Z J; Zeng, Y; Lan, P; Sun, P H; Chen, W M^*

来源：Mini Reviews in Medicinal Chemistry, 2011, 11(13): 1122-1129.

DOI：10.2174/138955711797655362

• Berberine
• structural modification
• biological activities

Berberine is an isoquinoline alkaloid isolated from Chinese herbs such as Coptidis Rhizome. This paper is a systematic review of the structural modifications of berberine for different biological activities such as antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, anti-inflammatory and antimalaria. The current review would provide some useful information for further studies on structural modification of berberine for discovering new drug leads.

• 出版日期2011-11
• 单位暨南大学