Pestalachlorides A-C, antifungal metabolites from the plant endophytic fungus Pestalotiopsis adusta

作者：Li Erwei; Jiang Lihua; Guo Liangdong; Zhang Hua; Che Yongsheng^*

来源：Bioorganic & Medicinal Chemistry, 2008, 16(17): 7894-7899.

DOI：10.1016/j.bmc.2008.07.075

• Pestalotiopsis adusta
• pestalachlorides
• antifungal
• atropisomer
• racemate

Pestalachlorides A-C (1-3), three new chlorinated benzophenone derivatives, have been isolated from cultures of an isolate of the plant endophytic fungus Pestalotiopsis adusta. The structures of these compounds were determined mainly by NMR spectroscopy, and the structures of 1 and 3 were further confirmed by X-ray crystallography. Pestalachloride A (1) was obtained as a mixture of two inseparable atropisomers (1a and 1b), whereas pestalachloride C (3) was found to be a racemic mixture. Compounds 1 and 2 displayed significant antifungal activities against three plant pathogens.

• 出版日期2008-9-1
• 单位中国科学院微生物研究所