Atypical case of Morvan's syndrome

作者：Lotan Itay^*; Djaldetti Ruth; Hellman Mark A; Benninger Felix

来源：Journal of Clinical Neuroscience, 2016, 25: 132-134.

DOI：10.1016/j.jocn.2015.06.025

• Guillain-Barre syndrome
• Morvan's syndrome
• Paraneoplastic syndrome
• Peripheral neuropathy

Morvan's syndrome is a rare neurological condition characterized by the combination of neuromyotonia, autonomic instability and encephalopathy, associated with auto-antibodies against voltage-gated potassium channels. We report a patient with an initial presentation suggestive of typical Guillain Barre syndrome (GBS), who later developed clinical and laboratory features compatible with Morvan's syndrome. Several months after resolution of the neurological symptoms, as well as disappearance of the characteristic anti-leucine-rich, glioma inactivated 1 (anti-LGII) antibodies, the patient presented with episodes of fever of unknown origin, during which the antibodies became positive again, suggesting the possibility of a relapse. In this case, both the GBS-like symptoms at presentation and the isolated episodes of fever of unknown origin during follow-up are atypical, and may suggest the presence of an additional, yet unknown antibody.

• 出版日期2016-3