NFAT and NF-kappa B factors - the distant relatives

作者：Serfling E^*; Berberich Siebelt F; Avots A; Chuvpilo S; Klein Hessling S; Jha MK; Kondo E; Pagel P; Schulze Luehrmann J; Palmetshofer A

来源：International Journal of Biochemistry & Cell Biology, 2004, 36(7): 1166-1170.

DOI：10.1016/j.biocel.2003.07.002

• apoptosis
• evolution
• immunity
• NEAT
• NF-kappa B

NFAT and NF-kappaB proteins are members of a superfamily of transcription factors whose activity plays a crucial role in the activation, proliferation and apoptosis of lymphocytes. Both types of factors share a number of properties, including similar DNA binding domains and rapid nuclear translocation upon antigenic stimulation. While NF-kappaBs control both innate and adaptive immune responses, NFATs control the adaptive immune system which emerged-in parallel with the appearance of the NFAT family-in jawed fish. However, NFATs and NF-kappaBs differ remarkably in their function. Whereas NFATs support activation-induced cell death (AICD) of T and B cells, NF-kappaB proteins frequently exert a strong anti-apoptotic effect on lymphocytes and other cells. While the anti-apoptotic activity of NF-kappaBs contributes to their oncogenic capacity, the pro-apoptotic activity favors NFATs as tumor suppressors in lymphoid cells.

• 出版日期2004-7