A continuous flow microwave-assisted fischer indole synthesis of 7-Ethyltryptophol

作者：Xu, Jianguo; Yu, Jiangang^*; Jin, Yi; Li, Jie; Yu, Zhiqun; Lv, Yanwen^*

来源：Chemical Engineering and Processing, 2017, 121: 144-148.

DOI：10.1016/j.cep.2017.09.001

• ORGANIC-SYNTHESIS
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• OVENS

A new procedure of microwave-assisted organic synthesis in flow was designed and introduced for Fischer indole synthesis of 7-ethyltryptophol (7-ET). By using back-pressure regulator (BPR), a reaction temperature of 180 degrees C could be easily and readily achieved even in a low-boiling solvent [water/ethylene glycol(EG)]. At this temperature, the synthesis of 7-ET from 2-ethylphenylhydrazine and 4-hydroxybutanal in flow was successful (78% net yield) and practical (short residence time: 30 s) with a simple purification process of extraction.

• 出版日期2017-11
• 单位浙江工业大学; 衢州学院