Molecular basis of cholera blood-group dependence and implications for a world characterized by climate change

作者：Holmner Asa; Mackenzie Alasdair; Krengel Ute^*

来源：FEBS Letters, 2010, 584(12): 2548-2555.

DOI：10.1016/j.febslet.2010.03.050

• Blood-group antigen recognition
• Cholera toxin
• Climate change/global warming
• Protein-carbohydrate interaction
• Structural biology
• Vaccine development

Climate change has the potential to increase the threat of water-borne diseases, through rises in temperature and sea-level, and precipitation variability. Cholera poses a particular threat, and the need to develop better intervention tools is imminent. Cholera infections are particularly severe for blood group O individuals, who are less protected by the current vaccines. Here we derive a hypothesis as to the molecular origins of blood-group dependence of this disease, based on relevant epidemiological, clinical and molecular data, and give suggestions on how to plan prevention strategies, and develop novel and improved pharmaceuticals.

• 出版日期2010-6-18