A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology

作者：Matarin Mar; Salih Dervis A; Yasvoina Marina; Cummings Damian M; Guelfi Sebastian; Liu Wenfei; Solim Muzammil A Nahaboo; Moens Thomas G; Paublete Rocio Moreno; Ali Shabinah S; Perona Marina; Desai Roshni; Smith Kenneth J; Latcham Judy; Fulleylove Michael; Richardson Jill C; Hardy John^*; Edwards Frances A

来源：Cell Reports, 2015, 10(4): 633-644.

DOI：10.1016/j.celrep.2014.12.041

We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid'' transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU'' transgenic mice (mutant human MAPT gene). Microarray data were validated by qPCR and by comparison to human studies, including genome-wide association study (GWAS) hits. Immune gene expression correlated tightly with plaques whereas synaptic genes correlated negatively with neurofibrillary tangles. Network analysis of immune gene modules revealed six hub genes in hippocampus of amyloid mice, four in common with cortex. The hippocampal network in TAU mice was similar except that Trem2 had hub status only in amyloid mice. The cortical network of TAU mice was entirely different with more hub genes and few in common with the other networks, suggesting reasons for specificity of cortical dysfunction in FTDP17. This Resource opens up many areas for investigation.

• 出版日期2015-2-3