New imaging tools for the diagnosis of infection

作者：Walker Ronald C^*; Jones Jackson Laurie B; Martin William; Habibian M Reza; Delbeke Dominique

来源：Future Microbiology, 2007, 2(5): 527-554.

DOI：10.2217/17460913.2.5.527

• F-18-FDG PET infection imaging
• cytokine imaging
• infection imaging
• in vivo white cell labeling
• radiolabeled ciprofloxacin
• radiolabeled white blood cells

Infection imaging became widespread in 1971 with the release of Ga-67 citrate. Multiphase skeletal scintigraphy and radiolabeled white blood cells (WBCs) have since become the most widespread clinically used agents for the imaging of infection. A wide variety of other radiolabeled probes are under investigation, based on antibodies, cytokines, assorted proteins and other molecules, alone or in various combinations. However, these latter agents, with a few exceptions, are not routinely used clinically. Radiolabeled ciprofloxacin represents the first attempt to develop an infection-specific imaging agent (most infection-imaging probes localized nonspecifically to inflammation as well), but it has not proven superior to radiolabeled WBCs or F-18-fluoro-deoxy-glucose (FDG) PET. Because of the ability to combine exquisite anatomic detail with focal uptake of F-18-FDG, PET-computed tomography has achieved great success in the detection and localization of infection, including in clinically adverse conditions. Despite these advances, at this time an infection-specific imaging agent does not exist.

• 出版日期2007-10