Asymmetric Synthesis of Spiro-3,4-dihydropyrans via a Domino Organocatalytic Sequence

作者：Yao Weijun; Pan Lianjie; Wu Yihua; Ma Cheng^*

来源：Organic Letters, 2010, 12(10): 2422-2425.

DOI：10.1021/ol1007873

A cinchona alkaloid-catalyzed domino Michael/hemiacetalization reaction of cyclic beta-oxo aldehydes and aromatic beta,gamma-unsaturated a-keto esters, resulting in the formation of spiro-dihydropyran architectures in good yield with high stereoselectivity (up to 97% ee), is presented.

• 出版日期2010-5-21
• 单位浙江大学