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摘要
The efficacy of NovaSil clay (NS) to reduce aflatoxin (AF) biomarkers of exposure was evaluated in 656 blood samples and 624 urine samples collected from study participants during a 3-month phase IIa clinical intervention trial in Ghana. NS was delivered before meals via capsules. Serum AFB(1)-albumin adduct was measured by radioimmunoassay and urinary AFM(1) metabolites were quantified by immunoaffinity-high-performance liquid chromatography (HPLC) -fluorescence methods. Levels of AFB(1)-albumin adduct in serum samples collected at baseline and at I month were similar (p=0.2354 and p=0.3645, respectively) among the placebo (PL), low dose (LD, 1.5g NS day(-1)), and high dose (HD, 3.0g NS day(-1)) groups. However, the levels of AFB(1)-albumin adduct at 3 months were significantly decreased in both the LD group (p < 0.000 1) and the HD group (p < 0.000 1) compared with levels in the PL group. Levels of AFM(1) in urine samples collected at baseline and at 1 month were not statistically different among the three study groups. However, a significant decrease (up to 58%) in the median level of AFM(1) in samples collected at 3 months was found in the HD group when compared with the median level in the PL group (p < 0. 039 1). In addition, significant effects were found for dose, time, and dose-time interaction with serum AFB(1)-albumin adduct and dose-time interaction with urinary AFM(1) metabolites. The results suggest that capsules containing NS clay can be used to reduce effectively the bioavailability of dietary AF based on a reduction of AF-specific biomarkers.
- 出版日期2008-5
- 单位河北医科大学
