科研之友
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摘要
The microvasculature is critical in the control of blood flow. Aging and reduced physical activity (PA) may both decrease microvascular function. Purpose: The primary aimwas to evaluate the influence of age onmicrovascular function in adults with similar PA levels. Secondary aims were to assess the reliability ofmuscle functionalmagnetic resonance imaging in older adults (OA) and the relationship between PA andmicrovascular function in OA. Methods: Microvascular blood-oxygen-level dependent (BOLD) responses were measured in young adults (YA, n = 12, mean +/- SD age = 21 +/- 1 yr old, PA = 239 +/- 73 x 10(3) counts per day) and OA (n = 13, 64 +/- 4 yr old, PA = 203 +/- 48 x 10(3) counts per day). Functional magnetic resonance images (3T, echo planar BOLD) of the leg were acquired after brief (1 s) maximal voluntary isometric contractions. The test-retest reliability of BOLD responses and the Pearson correlation between peak BOLD and PA were assessed in a group of OA (OA-r) with a broad range of PA (66 +/- 5 yr old, n = 9, PA range = 54 x 10(3) to 674 x 10(3) counts per day). Results: Peak BOLD microvascular responses were reduced for OA compared with YA. OA peak BOLD was 27% lower in the soleus (3.3% +/- 0.8% OA vs 4.5% +/- 1.4% YA; P = 0.017) and 40% lower in the anterior compartment (1.6% +/- 0.6% OA vs 2.7% +/- 1.1% YA; P = 0.006). Coefficients of variation were 8.6% and 11.8% for peak BOLD in the soleus and anterior compartment, respectively, with an intraclass correlation of 0.950 for both muscle regions. The correlation between peak BOLD and PA was r >= 0.715, P <= 0.030. Conclusions: Aging was associated with reduced microvascular function in leg muscles, independent of PA. The findings also revealed good reliability for BOLD magnetic resonance imaging in OA for the soleus and anterior compartment muscles.
- 出版日期2017-8
