A simple and fast-response fluorescent probe for hypochlorite in living cells

作者：Ji, Ruixue; Qin, Kun; Liu, Aikun; Zhu, Yan; Ge, Yanqing^*

来源：Tetrahedron Letters, 2018, 59(24): 2372-2375.

DOI：10.1016/j.tetlet.2018.05.027

• Pyrido[1,2-a]benzimidazole
• Hydrazone
• Bioimaging
• Fluorescent probe
• Hypochlorite

A novel fluorophore pyrido[l,2-a]benzimidazole was synthesized and used as a fluorescent probe for hypochlorite based on the oxidation of hydrazine to carboxyl group. The detection limit was measured to be as low as 7.0 nM. The probe can realize fast-detection for hypochlorite within 60 s. Furthermore, it could be used for imaging in living cells.

• 出版日期2018-6-13
• 单位山东第一医科大学