N- terminal pro- brain natriuretic peptide level determined at different times identifies transient ischaemic attack patients with atrial fibrillation

作者：Purroy F^*; Suarez Luis I; Mauri Capdevila G; Cambray S; Farre J; Sanahuja J; Pinol Ripoll G; Quilez A; Gonzalez Mingot C; Begue R; Gil M I; Fernandez E; Benabdelhak I

来源：European Journal of Neurology, 2014, 21(4): 679-683.

DOI：10.1111/ene.12222

• atrial fibrillation
• biomarker
• cardioembolic
• NT-proBNP
• transient ischemic attack

Background and purposeThe etiological classification of patients with transient ischaemic attack (TIA) is a difficultendeavor and the use of serum biomarkers could improve the diagnostic accuracy. The aim of this study was to correlate atrial fibrillation, the main cardioembolic etiology (CE), with different serum biomarkers measured in consecutive TIA patients. %26lt;br%26gt;MethodsThe concentrations of interleukin-6 (IL-6), tumor necrosis factor-alpha, neuron-specific enolase, high-sensitivity C-reactive protein, IL-1- and the N-terminal pro-B type natriuretic peptide (NT-proBNP) were quantified in the serum of 140 patients with TIA and 44 non-stroke subjects. Measurements were performed at different times throughout evolution: within 24h of symptoms onset and at days 7 and 90. %26lt;br%26gt;ResultsWith the exception of IL-6, all biomarkers were higher in TIA patients than in controls. NT-proBNP was significantly related to the presence or new diagnosis of AF at all time points analyzed. Furthermore, the baseline NT-proBNP level was significantly higher than values at the 7-day and 90-day follow-up. For this reason, different cut-off values were obtained at different times: 313pg/ml at baseline [odds ratio (OR) = 18.99, P%26lt;0.001], 181pg/ml at 7days (OR = 11.4, P=0.001) and 174pg/ml (OR=8.46, P%26lt;0.001) at 90days. %26lt;br%26gt;ConclusionHigh levels ofNT-proBNP determined during the first 3months after a TIA were associated withAF. Consequently, this biomarker may be useful to reclassify undetermined TIA patients as having disease of CE.

• 出版日期2014-4