SNP Variations in the 7q33 Region Containing DGKI are Associated with Dyslexia in the Finnish and German Populations

作者：Matsson Hans^*; Tammimies Kristiina; Zucchelli Marco; Anthoni Heidi; Onkamo Paivi; Nopola Hemmi Jaana; Lyytinen Heikki; Leppanen Paavo H T; Neuhoff Nina; Warnke Andreas; Schulte Koerne Gert; Schumacher Johannes; Noethen Markus M; Kere Juha; Peyrard Janvid Myriam

来源：Behavior Genetics, 2011, 41(1): 134-140.

DOI：10.1007/s10519-010-9431-4

• Fine-mapping
• Linkage
• Association
• TDT
• PDT
• Reading disability

Four genes, DYX1C1, ROBO1, DCDC2 and KIAA0319 have been studied both genetically and functionally as candidate genes for developmental dyslexia, a common learning disability in children. The identification of novel genes is crucial to better understand the molecular pathways affected in dyslectic individuals. Here, we report results from a fine-mapping approach involving linkage and association analysis in Finnish and German dyslexic cohorts. We restrict a candidate region to 0.3 Mb on chromosome 7q33. This region harbours the gene diacylglycerol kinase, iota (DGKI) which contains overlapping haplotypes associated with dyslexia in both Finnish and German sample sets.

• 出版日期2011-1