Macular Choroidal Thickness in Children: The Shandong Children Eye Study

作者：Zhang, Juan Mei; Wu, Jian Feng; Chen, Jian Hua; Wang, Ling; Lu, Tai Liang; Sun, Wei; Hu, Yuan Yuan; Jiang, Wen Jun; Guo, Da Dong; Wang, Xing Rong; Bi, Hong Sheng^*; Jonas, Jost B.

来源：Investigative Ophthalmology & Visual Science, 2015, 56(13): 7646-7652.

DOI：10.1167/iovs.15-17137

• choroidal thickness
• choroid
• optical coherence tomography
• leptochoroid
• Shandong Children Eye Study

PURPOSE. To examine the thickness of the macular choroid and its associations in school children aged 6 to 18 years. @@@ METHODS. The school-based cross-sectional Shandong Children Eye Study included 6026 (94.7%) of 6364 eligible children fulfilling the inclusion criterion of an age from 4 to 18 years. Spectral-domain optical coherence tomography (SD-OCT) was performed for a subgroup of 972 school children aged 6+ years. All participants underwent ocular examinations, including measurement of visual acuity, cycloplegic refractometry, biometry, and SD-OCT (enhanced depth imaging mode) for measurement of choroidal thickness. @@@ RESULTS. The study included 972 children (501 girls) with a mean age of 11.3 +/- 3.3 years (range, 6-18 years) and mean axial length of 24.10 +/- 1.56 mm (range, 16.57-28.82 mm). Mean choroidal thickness was thicker (P < 0.001) at 500 mu m temporal to the foveola (290 6 67 mu m) than in the subfoveal region (283 +/- 67 mu m; range, 113-507 mu m) and the region 500 mu m superior to the fovea (283 +/- 66 mu m), where it was thicker (P < 0.001) than at 500 mu m inferior of the foveola (281 +/- 66 mu m), and it was thinnest (P < 0.001) at 500 mu m nasal of the foveola (268 +/- 67 mu m). In multivariate analysis, thicker SFCT was (overall correlation coefficient r: 0.51) associated with shorter axial length (P < 0.001; standardized correlation coefficient beta: -0.48; B: -23.7; 95% confidence interval [CI]: -27.2 to -20.3), male sex (P = 0.006; beta: -0.08; B: -10.7; 95% CI: -18.3 to -3.11), and younger age (P = 0.04; beta: -0.07; B: -1.46; 95% CI: -2.85 to -0.07). @@@ CONCLUSIONS. As in adults, thicker SFCT in children and teenagers was markedly associated with shorter axial length, and to a lesser degree with male sex and older age. As in adults, increasing axial myopia in teenagers is associated with choroidal thinning and development of a leptochoroid.

• 出版日期2015-12
• 单位临沂市人民医院; 山东中医药大学