The small GTPase Rab5 homologue Ypt5 regulates cell morphology, sexual development, ion-stress response and vacuolar formation in fission yeast

作者：Tsukamoto Yuta; Katayama Chisako; Shinohara Miki; Shinohara Akira; Maekawa Shohei; Miyamoto Masaaki^*

来源：Biochemical and Biophysical Research Communications, 2013, 441(4): 867-872.

DOI：10.1016/j.bbrc.2013.10.158

• Rab5
• Fission yeast
• A small GTPase

Inner-membrane transport is critical to cell function. Rab family GTPases play an important role in vesicle transport. In mammalian cells, Rab5 is reported to be involved in the regulation of endosome formation, phagocytosis and chromosome alignment. Here, we examined the role of the fission yeast Rab5 homologue Ypt5 using a point mutant allele. Mutant cells displayed abnormal cell morphology, mating, sporulation, endocytosis, vacuole fusion and responses to ion stress. Our data strongly suggest that fission yeast Rab5 is involved in the regulation of various types of cellular functions.

• 出版日期2013-11-29