Analysis of the treatment of gliomas with SEC therapy combined with radiochemotherapy

作者：Wang F^*; Huang Q; Zhou L Y

来源：European Review for Medical and Pharmacological Sciences, 2015, 19(13): 2400-2405.

• Superantigen
• Glioma
• Combined modality therapy
• Staphylococcal enterotoxin C

OBJECTIVE: To investigate the anti-glioma effects of staphylococcal enterotoxin C (SEC) combined with surgery, radiotherapy and chemotherapy, and the IL-2 of lymphocytes activated by SEC.
PATIENTS AND METHODS: A total of 92 patients with gliomas which had been surgically removed, were randomly divided into a control, and treatment groups A (systemic application of SEC) and B (local application of lymphocytes activated by SEC). The treatment effects were observed on a CT scan of the head. The SEC's induction on the IL-2 secretion by lymphocytes was determined using immunohistochemistry and RT-PCR methods.
RESULTS: Clinical materials showed that the effective rate (CR and PR) in the control group was 32.0%. In the treatment group A, the effective rate was 51.6% and 63.6% in the group B. The IL-2 of lymphocytes secreting activity activated by SEC began to secrete IL-2 on the 1st day and reached a peak during the 3rd day and the 5th day.
CONCLUSIONS: As a superantigen, SEC combined with surgery, radiotherapy and chemotherapy can improve treatment. The lymphocytes activated by SEC can release IL-2.

• 出版日期2015-7
• 单位苏州大学; 宿州学院; 安徽医科大学