Anticancer Effects of Sandalwood (Santalum album)

作者：Santha Sreevidya; Dwivedi Chandradhar^*

来源：Anticancer Research, 2015, 35(6): 3137-3145.

• Sandalwood
• santalol
• cancer
• apoptosis
• cell cycle
• carcinogenesis
• angiogenesis
• review

Effective management of tumorigenesis requires development of better anticancer agents with greater efficacy and fewer side-effects. Natural products are important sources for the development of chemotherapeutic agents and almost 60% of anticancer drugs are of natural origin. alpha-Santlol, a sesquiterpene isolated from Sandalwood, is known for a variety of therapeutic properties including anti-inflammatory, anti-oxidant, anti-viral and anti-bacterial activities. Cell line and animal studies reported chemopreventive effects of sandalwood oil and alpha-santalol without causing toxic side-effects. Our laboratory identified its anticancer effects in chemically-induced skin carcinogenesis in CD-1 and SENCAR mice, ultraviolet-Binduced skin carcinogenesis in SKH-1 mice and in vitro models of melanoma, non-melanoma, breast and prostate cancer. Its ability to induce cell-cycle arrest and apoptosis in cancer cells is its most reported anticancer mechanism of action. The present review discusses studies that support the anticancer effect and the mode of action of sandalwood oil and alpha-santalol in carcinogenesis.

• 出版日期2015-6