An efficient multicomponent reaction for synthesis of 4-amino-6-aryl-2-alkylthiopyrimidine-5-carbonitrile derivatives

作者：Rong Liangce^*; Xia Sheng; Yin Shan; Tao Shimin; Zha Yunyun; Tu Shujiang

来源：Research on Chemical Intermediates, 2013, 39(8): 3699-3707.

DOI：10.1007/s11164-012-0873-6

• Multicomponent reactions
• 4-Amino-6-aryl-2-alkylthilpyrimidine
• Heterocyclic compound
• Synthesis

An efficient and facile synthesis of thiosubstituted pyrimidine derivatives (4-amino-6-aryl-2-alkylthiopyrimidine-5-carbonitrile derivatives) by one-pot multicomponent reaction of aromatic aldehydes, malononitrile, and S-methylisothiouronium sulfate (or S-benzylisothiourea hydrochloride) in ethanolic NaOH is reported. Because of the simple work-up procedure, low cost, and, especially, high product yields, this method is a useful and attractive procedure for synthesis of these thiosubstituted pyrimidine compounds.

• 出版日期2013-10