Online monitor of Aspirin crystallization process

作者：Li, Lanju; Li, Xiuxi^*; Xu, San

来源：Huagong Xuebao/CIESC Journal, 2018, 69(3): 1046-1052.

DOI：10.11949/j.issn.0438-1157.20171147

• Aspirin
• Attenuated total reflection Fourier transform infrared spectroscopy
• Crystal shapes
• Crystallization process
• On-line measurement
• Particle size analyzers
• Storage and transportations
• Two-dimensional imaging system

Size distribution and geometry are key properties of crystal products, which can affect product quality and downstream processes of filtration, drying, storage and transportation. An on-line process analysis system, including ultrasonic particle size analyzer, attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), turbidity analyzer and two-dimensional imaging system, was developed to monitor crystallization of Aspirin ethanol solution at various stirring and cooling rates. The results show that lower cooling or faster stirring rate produces more amount of fine crystals and higher cooling rate yields product with larger mean size and higher aspect ratio (AR). Therefore, adjusting cooling and stirring rate is an effective technique to control particle size distribution and shape of Aspirin crystals.

• 出版日期2018-3-1
• 单位华南理工大学