Niclosamide induces mitochondria fragmentation and promotes both apoptotic and autophagic cell death

作者：Park So Jung; Shin Ji Hyun; Kang Hee; Hwang Jung Jin; Cho Dong Hyung^*

来源：BMB Reports, 2011, 44(8): 517-522.

DOI：10.5483/BMBRep.2011.44.8.517

• Apoptosis
• Autophagy
• Fission
• Mitochondria dynamics
• Niclosamide

Mitochondrial dynamics not only involves mitochondrial morphology but also mitochondrial biogenesis, mitochondrial distribution, and cell death. To identify specific regulators to mitochondria dynamics, we screened a chemical library and identified niclosamide as a potent inducer of mitochondria fission. Niclosamide promoted mitochondrial fragmentation but this was blocked by down-regulation of Drp1. Niclosamide treatment resulted in the disruption of mitochondria membrane potential and reduction of ATP levels. Moreover, niclosamide led to apoptotic cell death by caspase-3 activation. Interestingly, niclosamide also increased autophagic activity. Inhibition of autophagy suppressed niclosamide-induced cell death. Therefore, our findings suggest that niclosamide induces mitochondria fragmentation and may contribute to apoptotic and autophagic cell death. [BMB reports 2011; 44(8): 517-522]

• 出版日期2011-8-31