Aryl-substituted aminobenzimidazoles targeting the hepatitis C virus internal ribosome entry site

作者：Ding Kejia; Wang Annie; Boerneke Mark A; Dibrov Sergey M; Hermann Thomas^*

来源：Bioorganic & Medicinal Chemistry Letters, 2014, 24(14): 3113-3117.

DOI：10.1016/j.bmcl.2014.05.009

• Antivirals
• HCV
• RNA targeting
• Translation inhibitor

We describe the exploration of N1-aryl-substituted benzimidazoles as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The design of the compounds was guided by the co-crystal structure of a benzimidazole viral translation inhibitor in complex with the RNA target. Structure-binding activity relationships of aryl-substituted benzimidazole ligands were established that were consistent with the crystal structure of the translation inhibitor complex.

• 出版日期2014-7-15