New 4-deoxy-(1 -> 3)-beta-D-glucan-based oligosaccharides and their immunostimulating potential

作者：Vetvicka Vaclav^*; Saraswat Ohri Sujata; Vashishta Aruna; Descroix Karine; Jamois Frank; Yvin Jean Claude; Ferrieres Vincent

来源：Carbohydrate Research, 2011, 346(14): 2213-2221.

DOI：10.1016/j.carres.2011.06.020

• Glucan
• Oligosaccharides
• Immunomodulators
• Phagocytosis

(1 -> 3)-beta-D-Glucans are well-established natural biological immunomodulators. However, problems inherited with the natural origin of these polysaccharides bring about significant setbacks, including batch-to-batch heterogeneity and significant differences based on the source and isolation techniques. In this study, we tried to overcome these problems by preparation of a quantitatively new set of oligo-(1 -> 3)-beta-D-glucan-based synthetic immunomodulators. Some of these non-natural oligosaccharides showed biological activities, such as stimulation of phagocytosis, modulation of gene expression, and anti-cancer activity, which were superior to natural glucans.

• 出版日期2011-10-18