Alpha-melanocyte stimulating hormone reduces putative stress-induced sickness behaviors in isolated guinea pig pups

作者：Schiml Webb PA^*; Deak T; Greenlee TM; Maken D; Hennessy MB

来源：Behavioural Brain Research, 2006, 168(2): 326-330.

DOI：10.1016/j.bbr.2005.08.022

• alpha-melanocyte stimulating hormone
• stress-induced sickness
• passive responses
• guinea pig
• maternal attachment
• sickness behavior

We have proposed that passive responses observed following maternal separation in guinea pig pups represent "stress-induced sickness behaviors" mediated by proinflammatory processes. In this study, the anti-inflammatory peptide, alpha-melanocyte stimulating hormone (alpha-MSH) administered intracerebroventricularly, but not intraperitoneally, reduced the passive responses of crouching, eye-closing, and extensive piloerection relative to levels following administration of vehicle. These findings support our hypothesis and are as would be expected if pro-inflammatory processes act centrally to promote the passive behaviors of separated guinea pig pups.

• 出版日期2006-4-3