Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: a report from the Children's Oncology Group

作者：Tarlock Katherine^*; Alonzo Todd A; Moraleda Pilar P; Gerbing Robert B; Raimondi Susana C; Hirsch Betsy A; Ravindranath Yaddanapudi; Lange Beverly; Woods William G; Gamis Alan S; Meshinchi Soheil

来源：British Journal of Haematology, 2014, 166(2): 254-259.

DOI：10.1111/bjh.12852

• acute myeloid leukaemia
• paediatric
• t(6
• 9)(p23
• q34)
• FLT3-ITD
• clinical outcome

Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is a rare subtype associated with FLT3-internal tandem duplication (ITD) and poor outcomes. The clinical outcomes of paediatric patients with t(6;9) with and without FLT3-ITD treated on six consecutive cooperative trails were evaluated. In contrast to patients without t(6;9), those with t(6;9) had a significantly lower complete remission rate, higher relapse rate (RR), and poor overall survival (OS). Within t(6; 9) patients, those with and without FLT3-ITD had an OS of 40% and 27% respectively (P > 0.9), demonstrating that t(6;9) is a high-risk cytogenetic feature in paediatric AML and its clinical impact is independent of the presence of FLT3-ITD.

• 出版日期2014-7