Antiinflammatory and analgesic activities of thesium chinense turcz extracts and its major flavonoids, kaempferol and kaempferol-3-O-glucoside

作者：Parveen Zahida; Deng Yulin; Saeed Muhammad Khalid; Dai Rongji; Ahamad Waqar; Yu Hong Yu

来源：Journal of the Pharmaceutical Society of Japan, 2007, 127(8): 1275-1279.

DOI：10.1248/yakushi.127.1275

• Thesium Chinense Turcz
• antiinflammatory activity
• carrageenan-induced paw edema
• ear edema
• kaempferol
• kaempferol-3-O-glucoside

The ethyl acetate, chloroform extracts, and the two flavonoids kaempferol 1 and kaempferol-3-O-glucoside 2 isolated from whole plants of Thesium chinense Turcz were investigated for their antiinflammatory and analgesic activities. For the antiinflammatory activity, carrageenan-induced hind paw edema and xylene-induced mouse ear edema models, and for the analgesic activity, the acetic acid-induced abdominal constriction test was used. The ethyl acetate extract and two flavonoids showed significant (p<0.05 and p<0.01) and dose-dependent antiinflammatory and analgesic activity. The chloroform extract was inactive in the assay.

• 出版日期2007
• 单位北京理工大学