Different thermic effects of leptin in adolescent females with varying body fat content

作者：Haas Verena K^*; Gaskin Kevin J; Kohn Michael R; Clarke Simon D; Mueller Manfred J

来源：Clinical Nutrition, 2010, 29(5): 639-645.

DOI：10.1016/j.clnu.2010.03.013

• Resting energy expenditure
• Leptin
• T-3
• Body composition
• Underweight
• Anorexia nervosa

Background & aims: Investigating the effect of leptin on energy expenditure in undernutrition might. lead to a better understanding of the role of leptin in regulating body weight in humans.
Methods: 73 underweight female adolescents with anorexia nervosa (AN) were compared with 23 healthy normal weight (nwC), and 9 overweight girls (OW); 37 AN were followed during 7 months of weight recovery. Resting energy expenditure (REE, by indirect calorimetry), body composition (fat mass, FM; lean tissue mass, LTM; by Dual-Energy X-Ray Absorptiometry) and plasma hormones of leptin and 3,5,3'-Triiodothyronine (T-3) were measured.
Results: In underweight, leptin, T-3 and REE adjusted for lean tissue mass (REELTM) were decreased; in OW, FM and leptin were increased at unchanged T-3 and REELTM. There was a significant positive relation between FM and leptin at low and normal (AN, r(2) = 0.26; nwC, r(2) = 0.51, p < 0.001), but not at high adiposity. Leptin and REELTM were positively associated in underweight (r(2) = 0.14, p = 0.001) but not in normal or overweight subjects. T-3 was linearly related to REELTM over the whole range of adiposity (r(2) = 0.42, p < 0.001). With weight gain in AN (5.0 +/- 3.5 kg) the relationship between leptin and REELTM changed toward the conditions seen in normal weight controls.
Conclusions: At low adiposity the interrelated fall of leptin and REE reflect an adaptive mechanism to preserve body weight. High leptin production associated with excessive adiposity was without effect on metabolic adaptation.

• 出版日期2010-10