Unmodified chiral primary amino alcohol as a new ligand for enantioselective alkynylation of aldehydes

作者：Xu Zhou; Mao Jincheng^*; Zhang Yawen

来源：Catalysis Communications, 2008, 10(1): 113-117.

DOI：10.1016/j.catcom.2008.08.006

• Amino alcohol
• Asymmetric alkynylation
• Phenylacetylene
• Enantioselectivity
• Propargylic alcohols

The unmodified available chiral amino alcohol 14 in combination with Ti((OPr)-Pr-i)(4) was found to catalyze the reaction of an alkynylzinc reagent with various aldehydes to generate chiral propargylic alcohols with moderate to good yields and enantioselectivities.

• 出版日期2008-10-10
• 单位宿州学院; 苏州大学