白塞病患者载脂蛋白E多态性和脂蛋白成分

作者：Tursen U.; Eskandari G.; Kaya T.I.; 张宪旗

来源：世界核心医学期刊文摘(儿科学分册), 2005, (05): 36.

Background. Behc.et’s disease (BD) is a multisystemic disease of unknown etio logy characterized by chronic relapsing oral-genital ulcers and uveitis. Some a bnormalities in lipoprotein metabolism have been described in patients with BD. Methods. In this study, apolipoprotein E (apo E) polymorphism and lipoprotein ch olesterol concentrations in 30 patients with BD were compared with those of 27 c ontrol subjects. Results. Both patients and controls were found to be normolipid emic. Patients with BD had significantly higher concentrations of high-density lipoprotein (HDL) cholesterol than those of controls (P < .0.05); however, there was no difference in serum triglyceride, low-densitylipoprotein(LDL)and very l ow-density lipoprotein (VLDL) cholesterol concentrations. The distribution of a po E genotypes and alleles was the same in both groups. There were slight differ ences in allele frequency between the groups, but this was not statistically sig nificant. Conclusions. The high HDL cholesterol levels observed in our patients were not related to abnormalities in apo E alleles.

• 出版日期2005