Deciphering the structure and function of Fc epsilon RI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm

作者：Manikandan Jayapal; Kothandaraman Narasimhan; Hande Manoor Prakash^*; Pushparaj Peter Natesan

来源：Cellular and Molecular Life Sciences, 2012, 69(12): 1917-1929.

DOI：10.1007/s00018-011-0886-0

• Allergy
• Anaphylaxis
• Fc epsilon RI
• IgE
• Cytokines
• Transcription
• Factors
• Functional
• Genomics

Allergy and anaphylaxis are inflammatory disorders caused by immune reactions mainly induced by immunoglobulin-E that signal through the high-affinity Fc epsilon RI receptor to release the inflammatory mediators from innate immune cells. The Fc epsilon RI/mast cell axis is potently involved in triggering various intracellular signaling molecules to induce calcium release from the internal stores, induction of transcription factors such as NF-kB, secretion of various cytokines as well as lipid mediators, and degranulation, resulting in the induction of allergy and anaphylaxis. In this review, we discuss various cellular and molecular mechanisms triggered through Fc epsilon RI/mast cell axis in allergy and anaphylaxis with a special emphasis on the functional genomics paradigm.

• 出版日期2012-6