Ultrasound Irradiation Promoted Large-Scale Preparation in Aqueous Media and Antioxidant Activity of Azoles

作者：Silva F A N; Galluzzi M P; Albuquerque B; Pizzuti L; Gressler V; Rivelli D P^*; Barros S B M; Pereira C M P

来源：Letters in Drug Design and Discovery, 2009, 6(5): 323-326.

DOI：10.2174/1570180810906050323

• Green chemistry
• Isoxazole
• Pyrazole
• Sonocatalysis
• ORAC
• DPPH

The scaled-up preparation of 1H-pyrazole, 1-phenylpyrazole and isoxazole via sonocatalysis is reported. The products were isolated in good yields in short time reaction. These compounds had been assayed for antioxidant activity by ORAC and DPPH methodologies. The results showed that only 1-phenylpyrazole presented good antioxidant activity compared with Trolox(R).

• 出版日期2009-7