Activation-induced cytidine deaminase and active cytidine demethylation

作者：Ramiro Almudena R; Barreto Vasco M^*

来源：TRENDS IN BIOCHEMICAL SCIENCES, 2015, 40(3): 172-181.

DOI：10.1016/j.tibs.2015.01.006

The regulation of demethylation in vertebrates has begun to be elucidated in the past decade. However, a possible involvement of activation-induced cytidine deaminase (AID) in this process remains uncertain. We survey the data supporting or casting doubt on such a role, and propose that there is no strong evidence for an involvement of AID in genome-wide active demethylation processes. Conversely, we present evidence that favors AID involvement in gene-specific demethylation events underlying cell differentiation.

• 出版日期2015-3