Automated Solid-Phase Synthesis of Hyaluronan Oligosaccharides

作者：Walvoort Marthe T C; Volbeda Anne Geert; Reintjens Niels R M; van den Elst Hans; Plante Obadiah J; Overkleeft Herman S; van der Marel Gij**ert A^*; Codee Jeroen D C

来源：Organic Letters, 2012, 14(14): 3776-3779.

DOI：10.1021/ol301666n

Well-defined fragments of hyaluronic acid (HA) have been obtained through a fully automated solid-phase oligosaccharide synthesis. Disaccharide building blocks, featuring a disarmed glucuronic acid donor moiety and a di-tert-butylsilylidene-protected glucosamine part, were used in the rapid and efficient assembly of HA fragments up to the pentadecamer level, equipped with a conjugation-ready anomeric allyl function.

• 出版日期2012-7-20