Morphologic and functional analysis of sperm and testes in Aquaporin 7 knockout mice

作者：Sohara Eisei; Ueda Otoya; Tachibe Takanori; Hani Toshio; Jishage Kou ichi; Rai Tatemitsu; Sasaki Sei; Uchida Shinichi^*

来源：Fertility and Sterility, 2007, 87(3): 671-676.

DOI：10.1016/j.fertnstert.2006.07.1522

• Aquaporin7
• AQP7
• testis
• sperm

Objective: To investigate the functional and morphological role of Aquaporin 7 (AQP7) in testis and sperm.
Design: Experimental laboratory study.
Setting: University and research institute unites.
Animal(s): AQP7 knockout mice (C57BL/6J background).
Interventions(s): None.
Main Outcome Measure(s): Morphologic analysis of testis and epididymis, daily sperm production, sperm motility, in vitro fertilization.
Result(s): There was no difference in the morphology of the testes and epididymis between AQP7 knockout and wild-type mice. The AQP7 knockout male mice and wild-type male mice had similar numbers of offspring. Analysis of the daily sperm production and motility of AQP7 knockout mice did not show any abnormalities. Similary, the rate of in vitro fertilization using sperm from AQP7 knockout mice was not different from wild-type mice.
Conclusion(s): Male AQP7 knockout mice were not sterile, and their sperm did not show any morpholic and functional abnormalities.

• 出版日期2007-3
• 单位河北医科大学