No evidence of NRAS mutation in squamous cell anal carcinoma (SCAC)

作者：Capelli Laura; Gardini Andrea Casadei; Scarpi Emanuela; Frassineti Giovanni Luca; Saragoni Luca; Puccetti Maurizio; Scartozzi Mario; Giannini Massimo; Tamberi Stefano; Corbelli Jody; Ulivi Paola

来源：Scientific Reports, 2016, 6(1): 37621.

DOI：10.1038/srep37621

Epidermal growth factor receptor (EGFR) is usually expressed in squamous cell anal carcinoma (SCAC) and anti-EGFR agents could represent a valid treatment strategy, also considering that KRAS and BRAF mutations are rare events in this type of cancer. However, no data are available on NRAS status in SCAC. In this study we analyzed NRAS status (exons 2-4) by Pyrosequencing in a case series of 50 SCAC patients previously characterized in our laboratory for KRAS, BRAF, PIK3CA mutations and HPV and HIV infections. We found no mutation in NRAS gene. These results confirm that since the principal anti-EGFR resistance mechanisms are almost absent in SCAC, anti-EGFR agents should be considered for the treatment of this type of cancer.

• 出版日期2016-11-25