Decorin treatment of spinal cord injury

作者：Esmaeili Maryam; Berry Martin; Logan Ann; Ahmed Zubair^*

来源：Neural Regeneration Research, 2014, 9(18): 1653-1656.

DOI：10.4103/1673-5374.141797

• spinal cord injury
• Decorin
• transforming growth factor-beta
• scarring
• chondroitin sulphate proteoglycan
• matrix metalloproteases

The scarring response after a penetrant central nervous system injury results from the interaction between invading leptominingeal/pericyte-derived fibroblasts and endogenous reactive astrocytes about the wound margin. Extracellular matrix and scar-derived axon growth inhibitory molecules fill the lesion site providing both a physical and chemical barrier to regenerating axons. Decorin, a small leucine-rich chondroitin-dermatan sulphate proteoglycan expressed by neurons and astrocytes in the central nervous system, is both anti-fibrotic and anti-inflammatory and attenuates the formation and partial dissolution of established and chronic scars. Here, we discuss the potential of using Decorin to antagonise scarring in the central nervous system.

• 出版日期2014-9