科研之友
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摘要
Background In experimentally induced cases of AA amyloidosis, the development of disease is enhanced by the administration of homogenous or heterogeneous amyloid fibrils. In recent years, cross-species transmission of animal amyloidosis into human has become of particular concern. Methods Cynomolgus monkeys (Macaca fascicularis) and C3H/HeN mice were inoculated with bovine amyloid fibrils under acute inflammation. Results Amyloid A deposits were not detected in any of the monkeys, but mild-to-severe AA deposits were found in all mice. Conclusions These results suggest that unlike in rodents, cross-species transmission of AA amyloidosis is less likely to develop, at least during acute inflammation, in primates.
- 出版日期2016-6
- 单位河北医科大学
